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KMID : 0386519990080010689
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Research Institute of Korean Medicone
1999 Volume.8 No. 1 p.689 ~ p.710
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The effect of Bobitang(BBT) water extract on spleen metabolic enzyme system as to aging process in rats
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李東濬/Lee, Dong-jun
吳旼錫/宋泰元/Oh, Min-suk/Song, Tae-won
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Abstract
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Bobitang(BBT) is one of the most important prescription that has been used in oriental medicine(dongyibogam) for recovering spleen condition. The study was done to evaluate effects of BBT water extract on the spleen lipid peroxide content and metabolic enzyme system changes. " After pretreatment of BBT I (100mg/kg), BBT 11 (250mg/kg), BBT III(350mg/kg), BBT N (500mg/kg) for 1 week, lipid peroxide content and metabolic enzyme system changes of the spleen was measured in 8 manths rats. The results were obtained as follows
1. The content of spleen lipid peroxide was significantly decreased in all experimental groups as compared with control, and best in BBT III IV treated groups.
2. The activity of spleen superoxide generation was significantly decreased in all experimental groups as compared with control, and best in BBT IV III treated groups.
3. The activity of cytochrome P-450 and aminopyrine demethylase warn t significant change.
4. The activity of aniline hydroxylase was significantly decreased in BBT IV H treated groups, xanthine oxidase was significantly decreased in all experimental groups, aldehyde oxidase was significantly decreased in BBT IV treated group as compared with control.
5. The activity of antioxidant enzymes as superoxide dismutase, catalase, glutathione peroxidase was significantly increased in all experimental groups as compared with control.
6. The activity of glutathion S-transferase was significantly increased in all experimental groups, the concentration of spleen glutathione was significantly increased in BBT IV treated group as compared with control.
7. The activity of r -glutamylcystein synthetase was significantly increased in BBT III N I treated groups as compared with control, the activity of glutathione reductase wasn t significant change.
From the above results, BBT is cosidered to have effect of remove peroxide content and free radical that was made during ageing process.
It is expected that treatment of BBT can be applied in future clinical study of delaying the ageing process.
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